7. Describe the Following Cell-surface Modifications Using the Table Below.

Adeno-associated virus AAV is recognized by glycosylated cell surface receptors of the host. AAV then traffics through the cytosol mediated by the cytoskeletal network.


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The cell surface proteome termed the surfaceome serves as the main communication hub between a cell and the extracellular environment Wollscheid et al 2009As such this cellular compartment often reveals the first signs of cellular distress and disease and is of substantial interest to the medical community for diagnostic and therapeutic development.

. 14-17 To evaluate the correlation between the variation in the binding capacity and the proteomics results we performed CSC on RPMI 1788 cells starting with 1000 μg of peptide pre-enrichment and used. This triggers internalization of the virus via clathrin-mediated endocytosis. One assignment at a time we will help make your academic journey smoother.

Owing to the somewhat low pH environment of the endosome the VP1VP2 region undergoes a conformational change. Cell surface capture CSC a chemoproteomic strategy for the identification of cell surface N-glycoproteins 9 was performed as we previously described in detail.


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